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KMID : 0616620040100010205
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Journal of Soonchunhyang Medical College
2004 Volume.10 No. 1 p.205 ~ p.212
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The Effects of Bio-ceramic Particles on Proliferation of Osteoblast
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Song Ho-Yeon
Ko Kwang-Kjune
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Abstract
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The important cause of re-operation in patients who received total hip arthroplasty is wear-debries-mediated osteolysis in bone-implant interface. We observed the effects of Al_(2)O_(3) and Ag-coated alumina (Al_(2)O_(3)-Ag) particles on the growth and morphologic changes of osteoblast. The results were compared with that of osteoblast cultured on Al_(2)O_(3), HAp-coated Al_(2)O_(3) and HAp-Ag composite Al_(2)O_(3) thin films. According to the effects of the particles, the cell number was decreased and the morphology of osteoblast was changed considerably compared with control. However, the proliferation of osteoblast cultured on HAp and HAp-Ag thin films were increased than control. These results suggest that the shape (particles) of material as well as characteristics of material itself may give a significant effect on the behavior of cell.
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KEYWORD
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Al_(2)O_(3) particle, osteoblast proliferation, MTT
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